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KMID : 0376219860230040535
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Chonnam Medical Journal
1986 Volume.23 No. 4 p.535 ~ p.542
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Effect of Propranolol and Droperidol pretreatment on Ephedrine induced arrhythmia during Halothane-N20 Anesthesia
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Abstract
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Halothane, in common use today, sensitizes the myocardium to endogenous and exogenous sympathomimetic amines and induces cardiac arrhythmia, sometimes life threatening. Sympathomimetic amines, however, are frequently injected subcutaneously for homeostasis or intravenously for cardiovascular stability.
Therefore, this study was performed to investigate the effect of propranolol 0.02 mg/kg and droperidol 0.1 mg/kg pretreatment on arrhythmias (A. R.) and changes in heart rate (H.R.), systolic blood pressure (S.B.P.) and diastolic blood pressure (D.B.P.) induced by I. V. administered ephedrine 0.2 mg/kg.
Patients were divided into 3. groups: 20 cases without pretreatment (Group I ), 10 cases with propranolol preatment (Group II ), and 20 cases with droperidol preatment (Group II)
The results were as follows:
1) In Group I , ephedrine produced A.R. in 16 cases(80%) and significant increase in H. R. (7-11 bpm, p<0.001) and S.B.P. (8-22 torr, p<0.001), but D.B.P. increased insignificantly (2-10 torr, NS).
2) In Group II , ephedrine produced A. R. in 3 cases (30%) and H. R. (6-8 bpm, p<0.05) decreased, but S.B.P. (12-21 torr, p<0.01) and D.B.P. (8-16 .torr, p<0.01) increased significantly.
3) In Group g[, ephedrine produced A.R. in 2 cases (10%) and H.R. (913 bpm, p<0.001) increased significantly, but S.B.P. and D.B.P. remained unaltered.
From the above results, it is concluded that propranolol or droperidol protects effectively against ventricular arrhythmia’s induced by ephedrine during halothane-N2O anesthesia in human volunteers.
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